Genetic analysis of hydroxymethylglutaryl‐coenzyme A reductase regulated degradation

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Hydroxymethylglutaryl‐coenzyme A reductase degradation occurs in the endoplasmic reticulum, and is regulated by the mevalonate pathway. In order to discover the molecules that mediate the degradation process and its control, we conducted a genetic analysis of the degradation of the yeast Hmg2p isozyme of hydroxymethylglutaryl‐coenzyme A reductase. Hmg2p degradation occurs by the action of HRD genes that direct Hmg2p to the ubiquitin‐proteasome pathway. Regulation of HRD‐dependent Hmg2p degradation appears to occur by the action of a separate set of CRD genes. Curr Opin Lipidol 9:93–97. © 1998 Rapid Science Ltd

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