CaaX converting enzymes

    loading  Checking for direct PDF access through Ovid

Abstract

Proteins that contain a carboxyl‐terminal CaaX motif undergo post‐translational processing involving prenylation, endoproteolysis and methylesterification. Two yeast genes, AFC1 and RCE1, which are candidates for genes encoding CaaX converting enzymes, were recently identified. Rce1p is required for the full penetrance of the activated Ras2pval19 phenotype in yeast, indicating its possible utility as a new target in Ras‐based malignancies. Advances in our current understanding of CaaX convertases and the functional importance of CaaX proteolysis are discussed. Curr Opin Lipidol 9:99–102. © 1998 Rapid Science Ltd

Related Topics

    loading  Loading Related Articles