Clarifying complex inheritance: apolipoprotein C3 and atherosclerosis


    loading  Checking for direct PDF access through Ovid

Abstract

Purpose of reviewTo describe some steps in the progress in the molecular biology of a peptide, apolipoprotein C3; its gene mutations that render individuals susceptible or resistant to developing hyperlipidaemia and atherosclerosis.Recent findingsData that lead to the development of a new therapeutic agent volanesorsen.SummaryThe agent blocks the function of the mRNA of apolipoprotein C3 and successfully treats severe hypertriglyceridaemia in phase 3 trials (Ionis Pharmaceuticals).

    loading  Loading Related Articles