Clarifying complex inheritance: apolipoprotein C3 and atherosclerosis

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Purpose of review

To describe some steps in the progress in the molecular biology of a peptide, apolipoprotein C3; its gene mutations that render individuals susceptible or resistant to developing hyperlipidaemia and atherosclerosis.

Recent findings

Data that lead to the development of a new therapeutic agent volanesorsen.


The agent blocks the function of the mRNA of apolipoprotein C3 and successfully treats severe hypertriglyceridaemia in phase 3 trials (Ionis Pharmaceuticals).

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