Inhibition of proliferation of a colon cancer cell line by indole-3-carbinol


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Abstract

ObjectiveTo observe the effect of Indole-3-carbinol (I3C), a naturally occurring component of cruciferous vegetables, on cell proliferation of a colon cancer cell line.MethodsCell proliferation was measured using three different methods; 3H-thymidine incorporation, cell count and colourimetric assay.ResultsEach method of measurement revealed that I3C significantly reduced cell proliferation at concentrations of > 0.1 mM.ConclusionThe present study demonstrates for the first time the capacity of indole-3-carbinol to inhibit cell proliferation of a colon cancer cell line.

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