Analysis of poorprognosis in colorectal mucinous adenocarcinoma: P116


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Abstract

Aim:Mucinous and non-mucinous adenocarcinomas were compared andprognostic factors were studied.Method:Five hundred and forty-six patients who underwent surgery for colorectal adenocarcinoma from January 2004 to December 2008 were included. From 2006, peritoneal fluid studies were performed among 271 patients.Results:Among the 546 patients, there were mucinous adenocarcinomas 30(5.5%) and 516 (94.5%) non-mucinous adenocarcinomas. Mean age was 55.0 for mucinous, 63.2 of non-mucinous colon cancers. They tend to develop in the right colon. Mucinous adenocarcinomas were more advanced in depth of invasion and distant metastasis, but no significant difference in LN metastasis. Peritoneal CEA, CA19-9, and positive cytology were more apparent. Liver and peritoneal metastasis did not show significant increases. Five year survival rates were 82.9%, 91.7% and cancer free survival rates were 42.7%, 68.5% each respectively for mucinous and non-mucinous cancers. According to stage, only III and IV patients showed differences in survival.Conclusion:Mucinous adenocarcinomas showed poorerprognosis and significant differences in recurrence, but had similarprognosis in early cancers. Although no significant differences were seen in LN metastasis, there were differences in infiltration depth. infiltrations led to the increase in free cancer cells and peritoneal fluid tumour markers: ultimately cancer recurrences developed.

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