T cell infiltration and patientprognosis in colorectal cancer: P140

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Aim:A dense infiltration of T cells in colorectal tumours is found more frequently in lower stage tumours, associated with a betterprognosis. The aim of this study was to relate the infiltration of T cells to cancer-specific survival in colorectal cancer, while taking tumour stage and other confounders into consideration.Method:The T cell marker CD3 was stained by immunohistochemical methods in 484 archival tumor tissue samples from the Colorectal Cancer in Umea Study. The density of T cells were semiquantitatively estimated and related to cancer-specific survival by Cox regression.Results:Patients whose tumours were highly infiltrated by T cells had a longer cancer-specific survival in multivariate analysis compared with those with low degrees of infiltration. Theprognostic value of T cell infiltration was independent of confounding factors such as age, sex, stage, tumour site and adjuvant chemotherapy. Furthermore, the finding was consistent across all stages, and statistically significant in multivariate analysis of stage II patients, in which the identification of risk factors for recurrence and cancer-specific death is of particular interest.Conclusion:Our results indicate that colorectal cancer patients whose tumours are highly infiltrated by T cells have a beneficialprognosis, especiallypronounced in stage II cancer.

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