Clinical significances ofpreoperative interleukin-6, vascular endothelial growth factor and serum C-reactiveprotein level in colorectal cancer: P091


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Abstract

Aim:To determine thepreoperative serum levels of interleukin-6 (IL-6), vascular endothelial growth factor (VEGF) and C-reactiveprotein (CRP) in colorectal carcinoma, and to correlate them with disease status andprognosis.Method:A total of 143 patients who underwent surgery for colorectal cancer were enrolled in this study. The relationship between IL-6, VEGF, CRP, various histological findings andprognosis was investigated.Results:The mean levels of IL-6, VEGF and CRP in colorectal cancer were significantly higher than in the normal control group; 13.77 ± 21.12 pg/ml vs 5.65 ± 1.34 pg/ml (P = 0.007); 620 ± 438 vs 334 ± 219 pg/ml (P < 0.001); 1.12 ± 2.39 mg/dl vs 0.43 ± 1.20 mg/dl (P = 0.010), respectively. Although IL-6, VEGF and CRP levels were not correlated with other pathological findings, VEGF level was significantly correlated with tumour size (r = 0.172, P = 0.012). When cut off values for IL6 (5.74 pg/ml), VEGF (541 pg/ml), CRP (0.23 mg/dl) were established at median levels, it was noted high VEGF levels were associated with reduced overall survival (P = 0.041). However, IL-6 and CRP results were not significantly associated with patients' disease free survival and overall survival.Conclusion:Preoperative serum IL-6, VEGF and CRP levels increase in colorectal cancer. High VEGF levels are an unfavourableprognostic factor in patients with colorectal cancer.

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