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To determine thepreoperative serum levels of interleukin-6 (IL-6), vascular endothelial growth factor (VEGF) and C-reactiveprotein (CRP) in colorectal carcinoma, and to correlate them with disease status andprognosis.A total of 143 patients who underwent surgery for colorectal cancer were enrolled in this study. The relationship between IL-6, VEGF, CRP, various histological findings andprognosis was investigated.The mean levels of IL-6, VEGF and CRP in colorectal cancer were significantly higher than in the normal control group; 13.77 ± 21.12 pg/ml vs 5.65 ± 1.34 pg/ml (P = 0.007); 620 ± 438 vs 334 ± 219 pg/ml (P < 0.001); 1.12 ± 2.39 mg/dl vs 0.43 ± 1.20 mg/dl (P = 0.010), respectively. Although IL-6, VEGF and CRP levels were not correlated with other pathological findings, VEGF level was significantly correlated with tumour size (r = 0.172, P = 0.012). When cut off values for IL6 (5.74 pg/ml), VEGF (541 pg/ml), CRP (0.23 mg/dl) were established at median levels, it was noted high VEGF levels were associated with reduced overall survival (P = 0.041). However, IL-6 and CRP results were not significantly associated with patients' disease free survival and overall survival.Preoperative serum IL-6, VEGF and CRP levels increase in colorectal cancer. High VEGF levels are an unfavourableprognostic factor in patients with colorectal cancer.