Control of pelvic symptoms in patients with rectal cancer and synchronous metastases: LTP73

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Aim:Optimal treatment strategy for rectal cancer (RC) with synchronous metastases remains an issue of debate. The aim of this study was to evaluate the impact of surgery and radiation on the control of pelvic symptoms in this setting.Method:Consecutive patients with RC and synchronous metastases were retrospectively assessed and divided into four treatment groups: surgical resection of rectal tumour (S); radiotherapy with/without chemotherapy followed by surgery (CRTS); chemo-radiotherapy (CRT); and chemotherapy only (CT). Each group was evaluated in terms of duration of pelvic symptom-free periods (relative to overall survival).Results:A total of 96 patients were evaluated: S: n = 30; CRTS: n =; CRT: n = 27; and CT: n = 18. After treatment, pelvic symptoms persisted in 14.7% patients (S = 0%, CRTS = 7.1%, CRT = 31.8%, CT = 25%; P = 0.01). The relative pelvic symptom-free periods were 93.0% in the S group, 83.1% in the CRTS group, 53.0% in the CRT group and 53.2% in the CT group (P < 0.01). On multivariate analysis, only surgical treatment correlated with a significant relative pelvic symptom-free period (P < 0.01), with an adjusted hazard ratio of 2.80 [95% CI: 1.79-4.39].Conclusion:Our results suggest that rectal resection was the most effective therapeuticprocedure in selected patients with RC and synchronous metastases, offering patients the longest pelvic symptomfree periods.

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