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The aim of this study was to detect Minimal Residual Disease (MRD) in bone marrow, portal and peripheral venous blood samples in a group of patiens with CRC, and subsuquently compare acquired outcomes with the clinical stadium of the disease and finally to evaluate the potential influence of MRDpresence on relapse.Included in the trial were patients withprimary CRC undergoing laparoscopic resection. One hundred and twenty-six patients (79.25%) were operated in stage I-III CRC. For measuring thepresence of MRD, six samples were taken from each patient. The real time RT-PCR methodology was used for MRD detection.We observed a correlation between MRD positivity in thepreoperative bone marrow sample and the stage of disease (P < 0.035). Correlations were also found between MRD findings in systemic venous blood samples takenpreoperatively and after resection (P < 10-5). The surgicalprocedure has an effect on MRD incidence in systemic venous blood in the group ofprimary negative patients (P < 0.025). Stage I-III patients with positive findings in systemic venous blood taken after surgery have a significantly reduced overall survival rate in the reference period compared with MRD-negative patients (P < 0.004).The obtained data suggest correlations between MRD andprognosis of the CRC disease.