Detection and clinical significance of minimal residual disease in colorectal cancer patients with laparoscopic resection: LTP62


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Abstract

Aim:The aim of this study was to detect Minimal Residual Disease (MRD) in bone marrow, portal and peripheral venous blood samples in a group of patiens with CRC, and subsuquently compare acquired outcomes with the clinical stadium of the disease and finally to evaluate the potential influence of MRDpresence on relapse.Method:Included in the trial were patients withprimary CRC undergoing laparoscopic resection. One hundred and twenty-six patients (79.25%) were operated in stage I-III CRC. For measuring thepresence of MRD, six samples were taken from each patient. The real time RT-PCR methodology was used for MRD detection.Results:We observed a correlation between MRD positivity in thepreoperative bone marrow sample and the stage of disease (P < 0.035). Correlations were also found between MRD findings in systemic venous blood samples takenpreoperatively and after resection (P < 10-5). The surgicalprocedure has an effect on MRD incidence in systemic venous blood in the group ofprimary negative patients (P < 0.025). Stage I-III patients with positive findings in systemic venous blood taken after surgery have a significantly reduced overall survival rate in the reference period compared with MRD-negative patients (P < 0.004).Conclusion:The obtained data suggest correlations between MRD andprognosis of the CRC disease.

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