|| Checking for direct PDF access through Ovid
The frequency of anal condyloma and anal intraepithelial neoplasia (AIN) is increasing. There are no clinical guidelines for the management of these patients.We analysed risk factors for and outcomes of patients treated for anal condyloma within a colorectal unit. Patients with diagnosis of anal condyloma were included in the Colorectalprospective database from 1994-2010. Risk factors for the development of anal condylomas, dysplasia and the results of treatment were analyzed.Thirty-six patients (27 male, 9 female) with a mean age of 36.5 (± 11.96) years and a mean follow-up of 20.41 (± 14.8) months were included. Twenty-eight (58.3%) were HIV positive and six (16.7%)practiced anal intercourse. Seven females (77.7%) had associated human papilloma HPV gynaecological lesions. Sixteen (44.4%) werepreviously treated by dermatologists. The most frequent operation was excision or fulguration in 26 (72%). The histological findings were: anal condyloma in 22 (61.1%), AIN-I in 2 (5.6%), AIN-II in 4 (11.1%), AIN-III in 7 (19.4%) and invasive carcinoma in one (2.8%). HPV16 genotype was analysed in only five patients (13.9%). Seven (19.4%) recurred. Variables such as HIV status, anal intercourse,previous treatments and associated lesions showed no significant risk for the development of dysplasia (P > 0.05).Currentpractice for condyloma is variable and a considerable % develop AIN-III/carcinoma. There is a need for the development ofprotocols for screening, diagnosis and treatment of these patients.