Early enteral feeding and the risk of necrotising enterocolitis: P045


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Abstract

Aim:Necrotizing enterocolitis (NEC) is the most common surgical gastroenterological emergency in neonates, with an unknown aetiology. We investigated the effect of early enteral feeding on NEC in neonated aged 24-32 weeks.Method:Thirty-seven case-control pairs were identified from neonates admitted to the Neonatal Intensive Care Unit (NICU) of British Columbia Children's Hospital, Vancouver between January 1st 2002 and December 31st 2007.Result:Early feeding was not associated with NEC (OR 0.6, 95% CI 0.79-1.47, P = 0.21). Sepsis was significantly associated with NEC (OR 6.5 95% CI 1.47, 28.8 P = 0.01). Neonates with NEC had longer duration on Total Parenteral Nutrition (TPN) (median days cases: 52, IQR 54; median days controls: 9, IQR 20, P = 0.0001) and longer admissions to the NICU (median days cases: 90, IQR 104; median days controls: 35 IQR 83, P = 0.003). Delayed enteral feeding (OR 1.67, 95% CI 0.61, 4.59, P = 0.45), neonates commenced on breast milk (OR 1.5, 95% CI 0.42, 5.32 P = 0.53) and formula fed neonates (OR 1.75, 95% CI 0.69-4.81 P = 0.30) were associated with increased odds of NEC, however results were not statistically significant.Conclusion:Neonates with NEC were more likely to have sepsis, required a higher number of days of TPN and longer NICU stays.

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