Factor associated withprognosis in patients undergoing intersphincteric resection for very low rectal cancer: P130


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Abstract

Aim:Intersphincteric resection(ISR) has been performing in patients with very low-lying rectal cancer forpreservation of anal function. We investigated risk factors associated withprognosis in patients undergoing ISR.Method:Data from 150 patients with very low rectal cancer who underwent curative resection between 2000 and 2007 were analyzed. Patients were stratified according to: ISR and ISR with patient's external sphincter resection (PESR) groups; T1/T2(£T2) and T3/T4(‡T3) groups, R0(radial margin > 1 mm) and R1(£1 mm) groups. Survival and local recurrence were investigated in these groups.Results:Five-year disease-free survival rate was 93% in £T2 group and 65% in ‡T3 group (P < 0.05), 76% in ISR and 52% in ISR with PESR group(P < 0.001). The 5-year local relapse-free survival rate was 87% in ISR and R0 groups, 75% in ISR with PESR and R1 groups (P < 0.05). These was also significant deference in the 5-years overall survival between R0 and R1 groups (P < 0.05).Conclusions:R1, ISR with PESR, and ‡T3 group are associated with worseprognosis in this curative operation. Powerfulpreoperative and postoperative adjuvant therapy may be needed in these groups.

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