Female fertility after pouch surgery: OP32

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Aim:To determine ifpregnancy rate is higher in females after laparoscopic restorativeproctocolectomy with ileo pouch anal anastomosis (IPAA) compared to open.Method:A questionnaire was sent to all female patients over 18 years that underwent IPAA surgery under age 41 in two centres between 1993 and 2009.Results:Ninety-five (86%) of the 111 patients responded. Following surgery, 28 (30%) patients attempted to conceive. Twelve (43%) patients underwent open and 16 (57%) underwent laparoscopic surgery. Median age at attempt to conceive was 29 (IQR 27-33). Cumulatively, of the patients that underwent open surgery, after 6 months and 1 year 4 (33%), and after 3 and 5 years 6 (50%) werepregnant. Cumulatively, of the 16 laparoscopically treated patients, after 6 months 7 (44%), after 1 year 9 (56%), after 3 and 5 years 12 (75%) werepregnant. Log rank between the groups showed no significant difference (P = 0.133). In the Netherlands the meanpregnancy rate at age 29 is 87% after 1 year; this is significantly higher compared to patients following laparoscopic or open surgery, P = 0.003 and P < 0.001, respectively.Conclusion:There is no significant difference in fecundity after laparoscopic or open IPAA surgery. Pregnancy rate is lower compared to general population.

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