The IL-13 -1112 C/T polymorphism and risk of sporadic colorectal cancer in a Polish population: LTP76


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Abstract

Aim:Colorectal cancer is one of the leading causes of death from cancer among adults. Studies that help in the better understanding of colorectal cancer on a molecular level mayprovide important tools for genetic screening for the disease high-risk groups, as well as molecular diagnostics for the noninvasive detection of cancer in its early-stage and may result in improved anti-cancer therapeutic agents. The aim of our research was to evaluate the association between colorectal cancer and the -1112 C>T single nucleotide polymorphism (SNP) of interleukin-13 gene.Method:In case-control study we genotyped 191 cancer patients and 205 healthy subjects from a Polish population. Analysis was performed by PCR-restriction fragment length polymorphism (PCR-RFLP).Results:We have found that C/T as well as T/T genotype is connected with higher risk of colon cancer occurrence (OR 2.41, 95% CI 1.59-3.65; P < 0.0001 and OR 3.72, 95% CI 1.1-13.73; P < 0.05, respectively). We observed the association between studied polymorphism and colorectalprogression evaluated by tumour stage as well as lymph node metastasis.Conclusion:Thepresent study suggests a link between the IL-13 gene polymorphism (-1112 C>T) and colorectal cancer risk in Polish population. It suggests that this polymorphism may play a role in colon cancer development.

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