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Constipation is a chronic bowelproblem with debilitating effects on patients' quality of life. This study aimed to evaluate the effectiveness of PTNS in patients with slow transit constipation.Twelve patients (11 women, median age 46.5 years [range 21-69]) with slow transit constipation participated in the study. Patients had 12 sessions (30 min per session) of PTNS with 1-3 sessions per week. Symptoms were evaluatedpre-and post-treatment using a standardised constipation score (score 0-31, 31 being worst) as theprimary outcome. Other outcome measures included colonic transit study, bowel diary and Patient Assessment of Constipation Quality of Life (PAC-QOL).Constipation score improved significantly from a median of 19 (range 10-24) to a median of 14.5 (range 9-20) (P = 0.014). The PAC-QOL also showed significant improvement from a median of 2.605 (range 1.360-3.610) to a median of 1.430 (0.390-3.780) (P = 0.046). Bowel frequency increased, the usage of laxatives and the number of retained markers in the colonic transit study both decreased, although they were not statistically significant.PTNS has potential as an affordable and minimally invasive treatment for slow transit constipation. A randomised controlled study is needed to establish the efficacy.