Prevalence of dysplastic and neoplastic lesions in patient with ileal J-pouch after restorativeproctocolectomy due to Familial Adenomatous Polyposis - 25 years ob follow-up: LTP34

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Aim:The aim of this study was to assess the incidence of pouch dysplasia/malignancy following surgery for Familial Adenomatous Polyposis.Method:This study describes a group of 165 patients who underwent aproctocolectomy during the period between 1985 and 2009. There were 86 female and 79 male patients. The mean age was 24.4 years.Results:Thepresence of dysplastic lesions or malignancy was identified in 15.8% of the patients. The patients were divided into two groups. The first group reflected patients who underwent surgery 0-10 yearsprior to the diagnosis of dysplasia or malignancy; the second group reflected patients with dysplasia or malignancy identified later then 10 years after the restorativeproctocolectomy. Thepredictedprevalence of low grade dyplasia 4 years after pouch surgery was 5% and 50% with a history of at least 15 years afterproctocolectomy.Conclusion:Due to the high risk of dysplasia in the pouch, every patient with an ileal pouch must be followed up by endoscopy and random biopsies. This is the only way toprotect the patient from malignancy in the pouch.

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