Prognostic factors and treatments of locally recurrent colorectal cancers: P153


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Abstract

Aim:To determineprognostic factors and to compare survival differences according to treatment modalities of locally recurrent colorectal cancers.Method:One hundred and one patients (3.2%) with local recurrence were identified among 3203 patients who underwent curative surgical resection (R0) between 2000 and 2007 at our centre. Median follow-up was 45 months.Results:The 5-year overall survival and recurrence-free survival rates were 85.0% and 76.8%. Local recurrence of colon and rectal cancers were 2% and 4.9%. In multivariate analysis of recurrence-free survival, tumor site, lymph node metastasis, distant metastasis, growth type of tumor, and lymphovascular invasion were independentprognostic factors. Most common site of the recurrences was the anastomosis site (n = 50, 50.0%), followed by regional lymph node (n = 22, 21.8%),primary operative site (n = 15, 14.9%), and pelvic cavity (n = 14, 13.9%). Surgical treatments of locally recurrent colorectal cancers were performed in 32 patients (31.7%)and curative re-resections were underwent in 21 patients (65.6%). Palliative chemotherapy and/or radiotherapy without surgical treatment were performed in 52 patients (51.5%). Patients with surgical treatment had a better 2-year survival than those without surgery (65.3% vs 37.3%). Among patients with surgical treatment, patients with curative re-resection had a better 2-year survival than those with palliative re-resection (68.4 vs 12.7%).Conclusion:We identified several significantprognostic factors of local recurrence in patients with colorectal cancers. Survival differences of patients with local recurrence were observed according to treatment modalities.

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