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Biological therapy may increase the risk of postoperative complications in patients with Crohn's disease. This study aimed to examine trends in reoperation rates in Crohn's disease in the biological era.Patients with Crohn's disease undergoing colorectal resection were identified from the Hospital Episode Statistics (HES) dataset between 2000 and 2008. Reoperation rates in 2000- 2005(timeA) were compared with those in 2006-2007(timeB). Reoperation was defined as reintervention for an intra-abdominal or wound complication during the index admission or upon readmission within 28 days of initial resection.Between 2000 and 2008, 11 920 patients underwent colorectal resection. 7.6% (901/11920) required reoperation. The mean number of cases per year was 1483 in timeB and 1511 in timeA. The reoperation rate increased in the latter study period [timeA 7.2%(639/8898); timeB 8.7%(262/3022), P = 0.007]. In multiple regression analysis, patients in timeB were more likely to require reoperation [odds ratio 1.24 (CI 1.07-1.44), P = 0.005] than those in the earlier time period.Further research is required to assess whether the increased reoperation rates observed in the latter study period reflect an increase in surgical complications in the biological era or are as a result of worsening disease severity.