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Routine use of small bowel capsule endoscopy (CE) for surveillance of patients with hereditary intestinal polyposis (HIP) is controversial. In 2009 we started aprospective study to assess the efficacy of CE and its impact on management of HIPs.CE-derived data of eight patients with HIP wereprospectively recorded and analysed in terms of morbidity, number, site and size of polyps, and impact on subsequent treatment.Of the eight patients, four had familial adenomatous polyposis (FAP), three had Peutz-Jeghers Syndrome (PJS) and one had Juvenile Polyposis (JP). All patients were symptom-free at the time of CE. All FAP patients had a 0-1 Spiegelmann score. No patient had CE-related complications, and capsule completed the small bowel study in all cases. Polyps or submucosal masses were observed in 87.5% of patients with 62.5% of them having significant changes in clinical management after CE. Five patients underwent endocopic polypectomy including two FAP, one PJS and one JP patients. One PJS patient with multifocal ileal carcinoid was sent to surgery.Our data confirm that CE is a safe and useful device for HIP surveillance leading to relevant changes of clinical management in the majority of patients.