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There is no consensus and scarce data in the literature when comparing side-to-side stapled over end-to-end handsewn technique for ileocolic anastomoses in laparoscopic colectomy. Aim: To compare the results of side-to-side stapled and end-to-end handswen methods for ileocolic anastomoses in laparoscopic colectomy.Patients who underwent an elective laparoscopic right colectomy were randomized to side-to-side stapled (GI) or end-to-end handsewn (GII) anastomoses. Primary outcome was anastomotic dehiscence. Secondary outcomes were: operating time, recovery of bowel function, other postoperative complications, reoperation and hospital stay. The calculated sample size to detect a 4% reduction in theprimary outcome was 93 patients per arm. Thepreliminary results of the first 60 patients are analized.Sixty patients accomplished the inclusion criteria (GI: 32; GII: 28). The patients were similar with respect to all baseline characteristics. Liquid and solid diet was significantly earlier in GII, however hospital postoperative stay was similar in both groups. No significant differences were found in terms of operative time, anastomostic dehiscence and other postoperative complications.Thepreliminary results of side-to-side stapled and end-to-end handsewn methods for ileocolic anastomoses in laparoscopic colectomy are similar in terms of postoperative recovery and morbidity.