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Single Incision laparoscopic Surgery (SILS) is of a growing interest, but very few cases have been reported so far. The aim of this study was to report ourpreliminary experience in colorectal surgery through SILS.From July 2009 to April 2010, 17 patients (seven males, 10 females) with a median age of 56 years underwent colorectal surgery through SILS (through the umbilicus); subtotal colectomy (n = 2), ileocolic resection (n = 3), right colectomy (n = 4), sigmoidectomy (n = 7) and totalproctectomy (n = 1), all for benign disease.Allprocedures were performed entirely through SILS, except for 2 (12%): one supplemental port was required during oneproctectomy and one patient was converted into laparoscopy for complicated diverticulitis. The median operative time was 160 min (range 100-240), and the size of umbilical port incision was 30 mm (range 25-50). No postoperative mortality and morbidity was observed, and the median hospital stay was 6 days (range 4-10). Regarding cosmetic results, 15 of 17 patients judged it excellent and better as expected.Thispreliminary experience suggests the technical feasibility and the safety of colorectal resection through SILS. Further studies comparing SILS to conventional laparoscopicprocedures are mandatory to assess both feasibility and benefits of this emerging technique.