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Although hypoxia inducible factor (HIF)-1a and stromal cell-derived factor (SDF)-1a are suggested to be involved in tumorigenicity and tumour angiogenesis, the clinicopathological significance of their expression in colorectal cancer is not fully understood. We examined HIF-1a, SDF-1a expression and microvessel density in colorectal cancers and investigated their relationship to clinicopathological features such as tumour staging, lymph node metastasis, vascular invasion (VI), lymphatic invasion (LI).Specimens of 83primary colorectal cancers were examined immunohistochemically. The relationships between clinicopathological features and microvessel density, HIF-1a, and SDF-1a expression were analyzed.Microvessel density was associated with tumour stage and LI. HIF-1a was associated with lymph node metastasis, tumour stage, VI and LI. SDF-1a was associated with nodal status, distant metastasis, tumour staging, VI and LI. Especially in microvessel densitythere was association between HIF-1aand SDF-1a. I am not sure what they mean by this sentence so may have interpreted it wrongly.We have demonstrated that SDF-1a levels are elevated in colorectal cancers and SDF-1a expression is correlated with lymph node metastasis, stage and distant metastasis in colorectal cancer. The expression of SDF-1a might be associated with tumourprogression and angiogenesis in colorectal cancer. Inhibition of SDF-1a could be a therapeutic option in colorectal cancer patients.