Stromal cell derived factor (SDF)-1-apromotes tumourprogression and angiogenesis in colorectal cancer: P087


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Abstract

Aim:Although hypoxia inducible factor (HIF)-1a and stromal cell-derived factor (SDF)-1a are suggested to be involved in tumorigenicity and tumour angiogenesis, the clinicopathological significance of their expression in colorectal cancer is not fully understood. We examined HIF-1a, SDF-1a expression and microvessel density in colorectal cancers and investigated their relationship to clinicopathological features such as tumour staging, lymph node metastasis, vascular invasion (VI), lymphatic invasion (LI).Method:Specimens of 83primary colorectal cancers were examined immunohistochemically. The relationships between clinicopathological features and microvessel density, HIF-1a, and SDF-1a expression were analyzed.Results:Microvessel density was associated with tumour stage and LI. HIF-1a was associated with lymph node metastasis, tumour stage, VI and LI. SDF-1a was associated with nodal status, distant metastasis, tumour staging, VI and LI. Especially in microvessel densitythere was association between HIF-1aand SDF-1a. I am not sure what they mean by this sentence so may have interpreted it wrongly.Conclusion:We have demonstrated that SDF-1a levels are elevated in colorectal cancers and SDF-1a expression is correlated with lymph node metastasis, stage and distant metastasis in colorectal cancer. The expression of SDF-1a might be associated with tumourprogression and angiogenesis in colorectal cancer. Inhibition of SDF-1a could be a therapeutic option in colorectal cancer patients.

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