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The occurrence of venous thromboembolism (VTE) manifesting as deep vein thrombosis(DVT) or pulmonary embolism(PE) after colorectal cancer surgery in Asian patients remains poorly characterized. Thepresent study investigated the incidence of symptomatic VTE in Korean colorectal cancer patients following surgery, and identified the associated risk factors.We retrospectively analyzed data from patients who developed symptomatic VTE after colorectal cancer surgery at our institute between 2006 and 2008. DVT was diagnosed using Doppler ultrasound or contrast venography, and PE using lung ventilation/perfusion scans or chest computed tomography. Thromboprophylaxis was used in patients considered at high risk of VTE.Of the 3645 patients, 31(0.85%) developed symptomatic VTE. Univariate analysis showed that history of VTE,preexisting cardiovascular and respiratory disease, operation time, immobilization time, and complications were associated with VTE. Multivariate analysis showed thatpreexisting cardiovascular disease, complications, advanced cancer stage, and immobilization time were risk factors for developing symptomatic VTE. The mean hospital stay was 18.3 days, and the mortality rate was 6.5%.The incidences of symptomatic VTE were found to be low in Asian colorectal cancer surgery patients. The risk factors for VTE werepreexisting cardiovascular disease, complications, advanced cancer stage, and immobilization. Thromboprophylaxis should be strongly considered in these patients. Largeprospective randomized controlled trials should be conducted to further evaluate the risk of VTE and to determine the optimalprophylaxis.