A method for history matching of an in-house petroleum reservoir compositional simulator with multipoint flux approximation is presented. This method is used for the estimation of unknown reservoir parameters, such as permeability and porosity, based on production data and inverted seismic data. The limited-memory Broyden–Fletcher–Goldfarb–Shanno method is employed for minimization of the objective function, which represents the difference between simulated and observed data. In this work, we present the key features of the algorithm for calculations of the gradients of the objective function based on adjoint variables. The test example shows that the method is applicable to cases with anisotropic permeability fields, multipoint flux approximation, and arbitrary fluid compositions.