Comparison of phenobarbital and pentobarbital actions upon water ingestion

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Differences in magnitude of facilitation of drinking by drugs suggested they have differing actions. To confirm this hypothesis, 18 rats in water balance were injected with phenobarbital, pentobarbital, or control solution ½ hr. before being given hypertonic saline to induce drinking. They were allowed to drink immediately. Phenobarbital reduced response latency and increased drinking; pentobarbital had no effect upon either measure. The Ss were then given pentobarbital or the control solution 5 hr. after saline administration and ½ hr. before having access to water. Pentobarbital then increased drinking well above control level. Conclusions are: (a) phenobarbital and pentobarbital differ in their action upon water ingestion; (b) phenobarbital, despite reduction of response latency, is not an adequate stimulus for drinking; (c) delay between saline administration and drinking introduces some condition not immediately elicited but not reflected in the volume ingested by comparable controls. (PsycINFO Database Record (c) 2006 APA, all rights reserved)

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