Training, drive level, and drug effects: A temporal analysis of their combined influence of behavior

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Effects of these variables on 4 time measures describing the essential or relevant components of a water-reinforced lever-pressing response, as well as on the time spent in irrelevant activities (grooming, sniffing, and sitting) were studied in 44 rats. Chlorpromazine decreased response rate at the 2 higher levels of training but not at the lowest level; methylphenidate decreased rate at the 2 lower drive levels but not a the highest. The response decrements were associated with a decrease in the speed of the relevant components in the case of chlorpromazine, and with an increase in time spent in irrelevant activities in the case of methylphenidate. A tentative generalization about the basis of differential effects of stimulant and depressant drugs on behavior is suggested. (PsycINFO Database Record (c) 2006 APA, all rights reserved)

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