Evaluation of the osmotic effects of glucose loads in food satiation


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Abstract

Osmotic theories of food intake predict that ingestion of hypertonic glucose and NaCl should concomitantly produce food satiety and thirst. 24 rats were tested, after ad-lib. feeding and 22-hr. food deprived. 2-hr. food and water intake tests followed stomach loads of sham tubing, or 3% body weight of water, 1 M glucose, or .5 M NaCl. Hunger increased all intakes without interacting with loads. Water, a known hydrator, decreased water intake without changing food intake. NaCl, a known dehydrator, decreased food and increased water intake. Glucose decreased food intake but also decreased water intake. NaCl satiety may be osmotic, but glucose, acting like a hydrator rather than a dehydrator, satiates via a metabolic rather than a colligative route. (PsycINFO Database Record (c) 2006 APA, all rights reserved)

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