Behavioral studies of immunosympathectomized mice

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Behavior of 63 Webster-Swiss mice, with a mean reduction of 88% in paravertebral sympathetic ganglion cells due to daily injection of nerve-growth-factor antiserum during the 1st 6 days of life, was tested over 4 mo. in open field, water maze, shock avoidance, runway with food reward, response to tone, and activity wheel. Controls were injected with bovine gamma globulin, handled without injection, or left undisturbed. Ss improved less than controls in aversive learning tasks but were comparable to controls in appetitive situations. It was concluded that their altered sympathetic functioning deprived immunosympathectomized Ss of internal cues that normally mediate avoidance and escape behavior. (18 ref.) (PsycINFO Database Record (c) 2006 APA, all rights reserved)

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