Cortical lesions resulting from chemically induced spreading depression

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Histology was performed on 31 rats subjected to various amounts of chemically induced cortical spreading depression (CSD). Daily 1- hr CSD sessions for as little as 2 days produced large cortical lesions on the depressed side. Noncortical structures were occasionally distorted but noncortical lesions were observed in only 2 cases. Results suggest that care should be taken in interpreting data from experiments involving CSD produced by topical application of KC1 in view of the accompanying permanent damage. (PsycINFO Database Record (c) 2006 APA, all rights reserved)

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