Operant behavior following unilateral and bilateral caudate lesion in the rat

    loading  Checking for direct PDF access through Ovid


Unilateral lesions of the caudate nucleus selectively blocked lever pressing with the forepaw contralateral to the lesion; response with the ipsilateral forepaw was not altered. These findings with 19 male albino rats were verified with 2nd-stage lesions of the opposite caudate, although 1-stage bilateral lesions produced more variable effects. Control ablation of sensorimotor cortex typically did not interfere with contralateral response and the integrity of sensorimotor cortex was not necessary for blocking of response induced by caudate lesions. Using 15 male Holtzman rats with other operant conditions and fixed interval (FI) reinforcing contingencies, bilateral caudate lesions disrupted preoperatively formed response suppression during early segments of each FI. These data implicate the caudate in sensorimotor functions and some form of inhibitory regulation of behavior. (16 ref.) (PsycINFO Database Record (c) 2006 APA, all rights reserved)

    loading  Loading Related Articles