Diallel analysis of avoidance conditioning in inbred strains of mice

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Tested 390 male and 390 female a/hej, akr/j, c58/j, balb/cj, swr/j, and 129/j mice in a 6 × 6 diallel-cross experimental design. Analysis through variance-covariance diagrams indicated that, in general, avoidance conditioning followed a dominant mode of inheritance. The dispersion of strains on the regression line indicated a polygenic system rather than single-gene action. Partitioning of the genetic variance produced statistically significant additive (a) and dominance (d) components, of approximately equal magnitude. Analysis by day of testing over 3 days demonstrated considerable changes in genetic parameters, but a systematic relationship between practice and heritability was not found. The finding that a greater degree of dominance was manifested in the early stages of conditioning suggests a 2-stage theory of avoidance learning. (PsycINFO Database Record (c) 2006 APA, all rights reserved)

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