Effects of hippocampal lesions upon the development of Pavlovian internal inhibition in rats


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Abstract

Trained 23 normal and hippocampal-damaged male long-evans rats to turn a wheel in order to avoid unsignaled shock. Following training, all ss received sessions of pavlovian fear conditioning in a separate chamber in which cs+ signaled the occurrence of unavoidable shock while cs- was never followed by shock. When these conditioned stimuli were subsequently presented to ss responding in the unsignaled shock-avoidance situation, normal ss demonstrated an increase in responding during cs+ and an attenuation in responding during cs-. While ss with hippocampal lesions similarly increased responding during cs+, no attenuation was observed during cs-. Results support the hypothesized role of the hippocampus in the development of internal inhibition. (23 ref.) (PsycINFO Database Record (c) 2006 APA, all rights reserved)

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