Genotype-dependent effects of d-amphetamine sulphate and caffeine on escape-avoidance behavior of rats

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Administered d-amphetamine sulphate and caffeine to 10 male and 10 female rats from each of 4 selectively bred strains to determine the effect on the number of avoidance responses, avoidance-response latency, escape-response latency, and intertrial crossings. The strains responded differentially to both drugs. Compared with the training period, the differences between nonreactive and reactive strains increased significantly and reversed their relative positions, and in high- and low-avoidance strains the differences decreased under the effects of both drugs. Findings show that the effect of both drugs on escape-avoidance behavior is dependent to a great extent on the biological material (strains) used. The methodological importance of these results is discussed. (PsycINFO Database Record (c) 2006 APA, all rights reserved)

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