A lateral preoptic osmosensitive zone for thirst in the rat


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Abstract

Conducted an experiment with 33 female sherman albino rats in which drinking to cellular dehydration but not to extracellular hypovolemia was abolished or attenuated in ss with bilateral destruction of the anteriomedial portion of the lateral preoptic area (lpo). Lesions medial or lateral to this critical zone had no effect on drinking. Drinking was mobilized in water-sated ss by the local dehydration of lpo or immediately adjacent tissue. Local rehydration of lpo suppressed drinking to systemic cellular dehydration. The effects were anatomically and physiologically specific: (a) dehydrating and rehydrating injections outside lpo into other hypothalamic structures were ineffective; and (b) drinking in response to renin was not attenuated by distilled water in lpo nor was the drinking of a liquid diet by hungry ss. Findings demonstrate that the lpo is the osmosensitive zone for thirst and strongly suggest that lpo contains a set of osmoreceptors for the mobilization of drinking behavior. (32 ref.) (PsycINFO Database Record (c) 2006 APA, all rights reserved)

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