Recovery of function following frontal brain damage in mice: Changes in sensitivity to amphetamine

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Studied the adrenergic drug sensitivity of frontal female cfi mice. Bilateral transsection of the frontal cerebral poles resulted in an initial impairment of passive-avoidance learning. This deficit is attributed to a partial failure of registration processes. Recovery of passive-avoidance learning in the frontal ss occurred as a function of time following surgery. Recovered frontal ss were found to be hyposensitive to impairment of passive-avoidance learning by d-amphetamine yet hypersensitive to impairment of habituation and/or enhancement of locomotor activity by d-amphetamine. Possible compensatory mechanisms responsible for recovery of function and changes in drug sensitivity are discussed. (18 ref.) (PsycINFO Database Record (c) 2006 APA, all rights reserved)

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