Model phenylketonuria (PKU) in the albino rat: Behavioral, biochemical, and neuroanatomical effects

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Model phenylketonuria was induced in Holtzman albino rats by injecting (at 1–20 days of age) and feeding (at 21–80 days) levophenylalanine and parachlorophenylalanine. Behavioral testing on an 8-item battery occurred twice: once while the Ss were either receiving the excess phenylalanines or not (original), and again following a 90-day drug-free recovery period (retention). Results indicate drug-dependent deficits in learning and activity on both original and retention tests. Serum phenylalanine, serum tryptophan, and liver phenylalanine hydroxylase activity levels were positively correlated with the behavioral deficit. Clumped dense material in some myelin sheaths and associated degeneration of axons were found in experimental Ss. (38 ref) (PsycINFO Database Record (c) 2006 APA, all rights reserved)

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