Posttrial d-amphetamine sulfate and one-trial learning in mice

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Conducted 3 experiments with a total of 216 male albino LACA mice to investigate the effect of dextroamphetamine sulfate on memory in such a way that (a) state-dependency learning effects were excluded, (b) the time of learning was known rather precisely, (c) the drug might be introduced rapidly after the learning trial if recovered, and (d) no previous learning experience or drug effects would be present to confound the interpretation of results. Results show that amphetamine (2 mg/Kg, iv) immediately after footshock on a 1-trial passive avoidance learning task impaired performance in retention tests 24 and 96 hrs later. When the injection was delayed by as little as 90 sec, no such impairment was seen. A similar injection immediately after the learning trial of a water-rewarded 1-trial appetitive task had no discernible effect on performance in retention trials 24 hrs and 6 wks later. It is argued that the effects of the amphetamines on learning behavior depend on whether reward or punishment is involved and, further, that all such effects could be accounted for in terms of the drugs' influence on memory mechanisms. (28 ref) (PsycINFO Database Record (c) 2006 APA, all rights reserved)

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