Role of estrogens in androgen-induced spontaneous activity in male rats

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Conducted 3 experiments with a total of 63 male and 12 female Sprague-Dawley rats to test the hypothesis that testosterone may be aromatized to an estrogen to stimulate running-wheel activity in rats. In Exp I, aromatizable (testosterone propionate; TP) and nonaromatizable (dihydrotestosterone propionate; DHTP) androgens were compared with estradiol benzoate (EB) for the ability to induce running in castrated males. DHTP had no effect on running. TP increased running, but EB was more than 100 times as effective. Results of Exp II show that relatively small doses of a specific estrogen antagonist, MER-25, attenuated the effects of both EB and TP on male running. Findings from Exp III indicate that the MER-25 did not affect the running of castrated, oil-treated males and did not inhibit the running induced by food deprivation. (30 ref) (PsycINFO Database Record (c) 2006 APA, all rights reserved)

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