Differential effects of the albino gene on behavior according to task, level of inbreeding, and genetic background

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Different generations from a Mendelian crossing schedule and 2 inbred recombinant albino strains of mice (BALB/cjOrl and C57BL/6jOrl) were compared in a water-escape and a locomotor task under dim red-orange light. Results reveal deleterious effects of the albino gene; it did not affect locomotor tasks but seriously altered cognitive capacities. The degree of expression of these effects was greater in the inbred albino Ss than in the albinos from heterozygous generations. Differences in the genetic background may also effect the degree of expression of the albino gene effects in various albino strains. The visual system is unlikely to mediate these pleiotropic effects of the albino gene. (31 ref) (PsycINFO Database Record (c) 2006 APA, all rights reserved)

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