Correlation of Apparent Diffusion Coefficient Value With Prognostic Parameters of Lung Cancer

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Purpose:The purpose of this study was to correlate the apparent diffusion coefficient (ADC) value with prognostic parameters of lung cancer.Methods:Thirty-one patients diagnosed with lung cancer (22 men, 9 women; mean age, 57 years) underwent diffusion-weighted magnetic resonance imaging of the chest using echo-planar imaging sequence with b factors of 0, 300, and 600 s/mm2. Apparent diffusion coefficient values were calculated and correlated with tumor grade and size as well as associated mediastinal lymph nodes. Institutional review board approval was obtained for this prospective study.Results:The mean ADC value of small cell lung cancer (1.02 ± 0.30 × 10−3 mm2/s) was significantly different (P = 0.025) from non-small cell lung cancer (1.39 ± 0.47 × 10−3 mm2/s). There was a significant difference in the ADC value between poorly and well-differentiated to moderately differentiated lung cancer (P = 0.03) as well as between patients with N0 and N3 mediastinal lymphadenopathy (P = 0.043). The ADC value of lung cancer correlated with tumor grade (r = −0.481, P = 0.043) and metastatic mediastinal nodes (r = −0.422, P = 0.018).Conclusions:Apparent diffusion coefficient value of the lung cancer can be considered as a new prognostic parameter. Lower ADC value of the lung cancer is associated with higher pathological tumor grade and metastatic lymph nodes.

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