The purpose of this study was to develop an interactive video instruction (IVI) program to teach registered nurses in the clinical setting concepts of quality improvement and to test the effectiveness of the program. The Smith Author System was used to combine text and video sequences repurposed from videodiscs developed for nursing education to describe and illustrate concepts of quality improvement. A sample of 55 registered nurses from a midwest regional medical center who used the program had a significant increase in knowledge (p<.05) from pre-to postprogram opinionnaire. More nurses with baccalaureate degrees scored above the median for the interactive video instruction program than those with associate degrees or diplomas. Registered nurses with more than 5 years of experience also expressed willingness to apply the concepts of quality improvement to their daily patient care activities and to use computers for learning.