Health care–associated infections (formerly called hospital-acquired infections or nosocomial infections) are a major public health concern. They place an enormous burden on the health care system, prolong hospitalization, and increase health care costs. Neurologists act as primary providers in the hospital or the clinic for patients with multiple comorbidities. We must be aware of the burden of health care–associated infections, their common types, risk factors, and various prevention strategies. Common strategies can be applied in day-to-day practice to help prevent health care–associated infections.