AbstractPurpose of Review:
Despite the efficacy of current therapies for relapsing forms of multiple sclerosis (MS), there remains a group of patients whose disease fails to respond and warrants a different approach to treatment. This article reviews this form of aggressive MS and proposes a definition and new treatment algorithm. Failing to recognize aggressive MS and initiate more effective therapy will result in a lost opportunity to effectively treat the disease.Recent Findings:
Natural history studies, together with the results of contemporary clinical trials, help to identify and profile a subset of patients with relapsing MS who have a much poorer prognosis and for whom conventional treatment tends to fail. Therapies that have shown success in the treatment of this patient group with aggressive MS are reviewed and discussed.Summary:
It is imperative to recognize aggressive MS to effectively treat it before patients progress. Recognizing aggressive MS as early as possible is the key to successful implementation of a proposed algorithm.