Biodegradable high-molecular-weight polymer drug carriers based on HPMA copolymers


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Abstract

Novel amphiphilic HPMA copolymers designed as polymer carriers of anticancer drugs (e.g. doxorubicin) were synthesised. In an aqueous environment the copolymers form supramolecular structures and thus increase drug accumulation in solid tumours due to the EPR (enhanced permeability and retention) effect. In addition, copolymers contain biodegradable linkages between hydrophilic polymer chains and hydrophobic molecules in order to allow disassembling of the supramolecular structure after completing their drug carrier function and renal removal of copolymers from the body.

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