Chitosan-based nanoparticles for cancer therapy; tumor specificity and enhanced therapeutic efficacy in tumor-bearing mice


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Abstract

Here, we report excellently tumor-homing chitosan-based nanoparticles for both cancer imaging and therapy, simultaneously, using the same particles. The tumor-homing nanoscale particles were prepared by the self-assembly of amphiphilic glycol chitosan polymer–cholanic acid conjugates. For the development of new nanoscale particles for tumor imaging and therapy, chitosan-based nanoparticles (CNPs) were simultaneously labeled with a near-infrared fluorescence (NIRF) dye, Cy5.5, and loaded with the anticancer drug, paclitaxel (PTX). Successful systemic administration of Cy5.5-labeled and PTX encapsulated CNPs into SCC7 tumor-bearing mice resulted in excellent tumor-homing ability, ultimately leading to early-stage cancer diagnosis, drug delivery, and therapy, simultaneously. These results indicate that it may be possible to develop nanoscale particles in cancer therapy.

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