Immunonanoparticles for targeting and delivery of protein drugs into tumour cells

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Cystatin, a protein inhibitor of cysteine proteases with potential antitumoural activity, was incorporated in poly(lactide-co-glycolide) nanoparticles, which were further surface-modified with monoclonal antibody, recognizing specific antigen overexpressed on invasive breast tumour cells (MCF-10A neoT). Results showed that immunonanoparticles were able to recognize and target the antigen on MCF-10A neoT cells in a co-culture with other cells. Following endocytosis, cystatin delivered by immunonanoparticles (immuno-NPs), effectively inhibited intracellular cathepsin B only in the target cells.

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