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Enhancing the oral bioavailability of hydrophobic drugs is an important topic, especially for patients lacking bile production (cholestasis). Polymeric micelles have been suggested as possible oral delivery systems. Using a cholestatic animal model, we showed that uptake of vitamin K formulated in thermosensitive polymeric micelles is not possible without bile acids. Bile acids are required to extract the drug from the micelles and to deliver it to the endothelial lining.