Injectable chitosan-based hydrogels for drug delivery after ear–nose–throat surgery

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Abstract summaryInjectable chitosan (CS)-based hydrogels were evaluated for their potential as drug delivery matrix to be applied as sealant after ear–nose–throat surgery. CS/genipin formulations showed relatively slow gelling, sufficient strength after gelling and controlled drug delivery profiles for dexamethasone. Crosslinking CS with oxidized polymeric materials may be more promising, since gelling times could be significantly reduced without affecting the other properties. Both CS-based hydrogels showed excellent antimicrobial properties towards Staphylococcus aureus.

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