Lipid based microparticles for Lab-on-a-chip application: Factorial design evaluation of influence of formulation and process parameters

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This study outlines the effect of the preparation parameters on the characteristics of lipospheres in order to obtain microparticles suitable for Lab-on-a-chip applications. The preliminary phase of the work was devoted to the selection of the best lipid composition by a classical intuitive approach while the optimization and the screening of the experimental parameters were conducted through a “design of experiments”. In the second part the loading, distribution and movement of lipid microparticles on DEParray(tm) Chip were analysed.

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