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Magnetic targeting is a technique that rapidly accumulates complexes containing drugs or gene vectors at target sites by means of a magnetic field. The effect of magnetic targeting on the cellular internalization pathway has not yet been elucidated. Using widefield fluorescence microscopy, we studied the uptake dynamics of magnetic lipoplexes in vitro. By single particle tracking, three modes of motion were found: directed motion on the cell membrane, confined diffusion and directed motion along microtubules.